Snake-like proteins can wrangle DNA

It turns out the coiled snakes often used to symbolize medical knowledge are more than apt. They also mimic a key to life itself.advertisement Members of Rice’s Center for Theoretical Biological Physics (CTBP) are taking a deep dive into the dynamics of essential proteins that help DNA fold into its compact, functional form in chromosomes. […]

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Alzheimer ‘tau’ protein far surpasses amyloid in predicting toll on brain tissue

Brain imaging of pathological tau-protein “tangles” reliably predicts the location of future brain atrophy in Alzheimer’s patients a year or more in advance, according to a new study by scientists at the UC San Francisco Memory and Aging Center. In contrast, the location of amyloid “plaques,” which have been the focus of Alzheimer’s research and […]

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Gone fishin’ — for proteins

Using a new microscopic “fishing” technique, scientists at the Montreal Clinical Research Institute (IRCM) and Université de Montréal have successfully snagged thousands of proteins key to the formation of the cell skeleton.advertisement Led by UdeM cell biologist Jean-François Côté, the team threw 56 “baits” into human cells they were incubating in their laboratory, catching more […]

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The secret to a long life? For worms, a cellular recycling protein is key

Longevity clock concept illustration (stock image).Credit: © iQoncept / Adobe Stock Scientists at Sanford Burnham Prebys Medical Discovery Institute have shown that worms live longer lives if they produce excess levels of a protein, p62, which recognizes toxic cell proteins that are tagged for destruction. The discovery, published in Nature Communications, could help uncover treatments for age-related […]

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Little-known protein appears to play important role in obesity and metabolic disease

With unexpected findings about a protein that’s highly expressed in fat tissue, scientists at Scripps Research have opened the door to critical new understandings about obesity and metabolism. Their discovery, which appears Nov. 20 in the journal Nature, could lead to new approaches for addressing obesity and potentially many other diseases.advertisement The signaling protein, known as […]

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