CRISPR-Cas9 datasets analysis leads to largest genetic screen resource for cancer research

A comprehensive map of genes necessary for cancer survival is one step closer, following the validation of the two largest CRISPR-Cas9 genetic screens in 725 cancer models, across 25 different cancer types. Scientists at the Wellcome Sanger Institute and the Broad Institute of MIT and Harvard compared the consistency of the two datasets, independently verifying […]

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Can good sleep patterns offset genetic susceptibility to heart disease and stroke?

Getting a good night’s sleep could be beneficial for long-term health. A pioneering new study led by Dr. Lu Qi, director of the Tulane University Obesity Research Center, found that even if people had a high genetic risk of heart disease or stroke, healthy sleep patterns could help offset that risk. The study is published […]

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The rare genetic disorder identified in only 3 people worldwide

A team of South Australian researchers has cracked a rare gene variant for a disorder that causes severe neurodegeneration in infants.advertisement The previously baffling condition sees a normal healthy child start to lose muscle tone and motor skills, ultimately losing the capacity to walk and use language. The children go on to experience epileptic encephalopathy […]

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Genetic brain disorder fixed in mice using precision epigenome editing

Using a targeted gene epigenome editing approach in the developing mouse brain, Johns Hopkins Medicine researchers reversed one gene mutation that leads to the genetic disorder WAGR syndrome, which causes intellectual disability and obesity in people. This specific editing was unique in that it changed the epigenome — how the genes are regulated — without […]

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Genetic discovery holds implications for better immunity, longer life

Caenorhabditis elegans (stock image).Credit: © heitipaves / Adobe Stock Wrinkles on the skin of a microscopic worm might provide the key to a longer, healthier life for humans.advertisement Working with Caenorhabditis elegans, a transparent nematode found in soil, researchers at Washington State University’s Elson S. Floyd College of Medicine were the first to find that the nervous system […]

Read More Genetic discovery holds implications for better immunity, longer life