Cancer-causing culprits will be caught by their DNA fingerprints

Illustration of cancer cells (stock image).Credit: © peterschreiber.media / Adobe Stock Causes of cancer are being catalogued by a huge international study revealing the genetic fingerprints of DNA-damaging processes that drive cancer development. Researchers from the Wellcome Sanger Institute, Duke-NUS Medical School Singapore, University of California San Diego School of Medicine, the Broad Institute of MIT […]

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Genome stability: Intricate process of DNA repair discovered

DNA illustration (stock image).Credit: © Design Cells / Adobe Stock An elaborate system of filaments, liquid droplet dynamics and protein connectors enables the repair of some damaged DNA in the nuclei of cells, researchers at the University of Toronto have found. The findings further challenge the belief that broken DNA floats aimlessly — and highlight the […]

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DNA Damage to Breast Cells from chemicals in some cosmetics, sunscreens

A new approach to studying the effects of two common chemicals used in cosmetics and sunscreens found they can cause DNA damage in breast cells at surprisingly low concentrations, while the same dose did not harm cells without estrogen receptors.advertisement The research, published Jan. 15 in Environmental Health Perspectives, identifies a new mechanism by which estrogens […]

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Snake-like proteins can wrangle DNA

It turns out the coiled snakes often used to symbolize medical knowledge are more than apt. They also mimic a key to life itself.advertisement Members of Rice’s Center for Theoretical Biological Physics (CTBP) are taking a deep dive into the dynamics of essential proteins that help DNA fold into its compact, functional form in chromosomes. […]

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How cells relieve DNA replication stress

DNA stores all of the information necessary for life phenomena, and a cell transmits its own genetic information to two daughter cells through DNA replication and cell division. Replication stress can be caused by extracellular and intracellular sources during DNA replication, which leads to slowed or stalled replication. If cells do not properly cope with […]

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For CRISPR, tweaking DNA fragments before inserting yields highest efficiency rates yet

University of Illinois researchers achieved the highest reported rates of inserting genes into human cells with the CRISPR-Cas9 gene-editing system, a necessary step for harnessing CRISPR for clinical gene-therapy applications.advertisement By chemically tweaking the ends of the DNA to be inserted, the new technique is up to five times more efficient than current approaches. The […]

Read More For CRISPR, tweaking DNA fragments before inserting yields highest efficiency rates yet