Mimicking cancer’s evasive tactics, microparticles show promise for transplant rejection

Organ transplant word cloud concept illustration (stock image).Credit: © Kheng Guan Toh / Adobe Stock Inspired by a tactic cancer cells use to evade the immune system, University of Pittsburgh researchers have engineered tiny particles that can trick the body into accepting transplanted tissue as its own.advertisement Rats that were treated with these cell-sized microparticles developed […]

Read More Mimicking cancer’s evasive tactics, microparticles show promise for transplant rejection

Mimicking cancer’s evasive tactics, microparticles show promise for transplant rejection

Organ transplant word cloud concept illustration (stock image).Credit: © Kheng Guan Toh / Adobe Stock Inspired by a tactic cancer cells use to evade the immune system, University of Pittsburgh researchers have engineered tiny particles that can trick the body into accepting transplanted tissue as its own.advertisement Rats that were treated with these cell-sized microparticles developed […]

Read More Mimicking cancer’s evasive tactics, microparticles show promise for transplant rejection

Origins of immune system mapped, opening doors for new cancer immunotherapies

Human thymus illustration (stock image).Credit: © nerthuz / Adobe Stock A first cell atlas of the human thymus gland could lead to new immune therapies to treat cancer and autoimmune diseases. Researchers from the Wellcome Sanger Institute, Newcastle University and Ghent University, Belgium, mapped thymus tissue through the human lifespan to understand how it develops and […]

Read More Origins of immune system mapped, opening doors for new cancer immunotherapies

Cancer-causing culprits will be caught by their DNA fingerprints

Illustration of cancer cells (stock image).Credit: © peterschreiber.media / Adobe Stock Causes of cancer are being catalogued by a huge international study revealing the genetic fingerprints of DNA-damaging processes that drive cancer development. Researchers from the Wellcome Sanger Institute, Duke-NUS Medical School Singapore, University of California San Diego School of Medicine, the Broad Institute of MIT […]

Read More Cancer-causing culprits will be caught by their DNA fingerprints

Researchers investigate molecule, VISTA, which keeps immune system quiet against cancer

While strong immune responses are needed to help protect the host from infections, the immune system also must curb the magnitude of those responses to limit the damage it can potentially cause. Over the past 8-10 years, a team of researchers at Dartmouth’s and Dartmouth Hitchcock’s Norris Cotton Cancer Center, led by Randolph Noelle, PhD, […]

Read More Researchers investigate molecule, VISTA, which keeps immune system quiet against cancer

Cancer mortality continues steady decline, driven by progress against lung cancer

The cancer death rate declined by 29% from 1991 to 2017, including a 2.2% drop from 2016 to 2017, the largest single-year drop in cancer mortality ever reported. The news comes from Cancer Statistics, 2020, the latest edition of the American Cancer Society’s annual report on cancer rates and trends.advertisement The steady 26-year decline in overall […]

Read More Cancer mortality continues steady decline, driven by progress against lung cancer

Half the amount of chemo prevents testicular cancer from coming back, new trial shows

Testicular cancer can be prevented from coming back using half the amount of chemotherapy that is currently used, a new clinical trial has shown.advertisement In many men who have had surgery for an aggressive form of testicular cancer, the disease can come back elsewhere in their bodies and need intensive treatment, often within two years […]

Read More Half the amount of chemo prevents testicular cancer from coming back, new trial shows

Using a chip to find better cancer fighting drugs

Kyoto University researchers have developed a new ‘tumor-on-a-chip’ device that can better mimic the environment inside the body, paving the way for improved screening of potential cancer fighting drugs.advertisement The path to drug discovery is never easy. Scientists and clinicians can go through tens-of-thousands of potential compounds for years to find a handful of viable […]

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Many younger patients with stomach cancer have a distinct disease

Many people under 60 who develop stomach cancer have a “genetically and clinically distinct” disease, new Mayo Clinic research has discovered. Compared to stomach cancer in older adults, this new, early onset form often grows and spreads more quickly, has a worse prognosis, and is more resistant to traditional chemotherapy treatments, the study finds. The […]

Read More Many younger patients with stomach cancer have a distinct disease

CRISPR-Cas9 datasets analysis leads to largest genetic screen resource for cancer research

A comprehensive map of genes necessary for cancer survival is one step closer, following the validation of the two largest CRISPR-Cas9 genetic screens in 725 cancer models, across 25 different cancer types. Scientists at the Wellcome Sanger Institute and the Broad Institute of MIT and Harvard compared the consistency of the two datasets, independently verifying […]

Read More CRISPR-Cas9 datasets analysis leads to largest genetic screen resource for cancer research